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You are here:Home»Products»Cultivation Systems»Glass Autoclavable Lab Scale Bioreactors

Glass Autoclavable Lab Scale Bioreactors

General

Glass autoclavable bioreactors

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Introduction
In the laboratory bioreactor and fermentor range Applikon is worldwide market leader because of its dependable and easy to use systems. The bioreactors and fermentors excel in quality and modularity. An Applikon laboratory system is easy to upgrade if a change in research activities occurs. Applikon offers glass autoclavable bioreactors for cell culture applications and glass autoclavable fermentors for microbial culture applications. The systems are built according to the specific demands of a process using an extensive array of standard components. Because of the modularity and flexibility, the user can always adapt the systems to changed process demands. This results in low initial investment and low running costs. The stirred tank reactor (STR) is the most widely used bioreactor type. Glass autoclavable bioreactors and fermentors are available in 1 - 2 - 3 - 5 - 7 - 15 and 20 liter total volume.

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Specifications

Autoclavable bioreactor specifications:

 

Total volume (liter)

Working volume (liter)

Minimum working volume (liter)

Aspect ratio total volume

Aspect ratio working volume

1 liter

1

0.9

0.3

1.9

1.5

2 liter single wall

2 liter jacketed

2

2

1.7

1.7

0.5

0.5

2.2

1.9

1.9

3 liter single wall

3 liter jacketed

3

3

2.7

2.7

0.5

0.5

1.7

1.5

1.5

5 liter single wall

5 liter jacketed

5

5

3.4

3.4

2.0

2.0

1.6

1.1

1.1

7 liter single wall

7 liter jacketed

7

7

5.4

5.4

2.0

2.0

2.3

1.8

1.8

15 liter single wall

15 liter jacketed

15

15

12

12

2.5

2.5

1.9

1.5

1.5

20 liter single wall

20

16

2.5

2.5

2.0

Drive system

Direct drive, lipsealed or magnetically coupled

Maximum stirrerspeed (rpm)

Standard range is 50 - 1250.

1, 2 and 3 liter systems can be supplied with 2000 rpm motor

Impellers

Rushton and marine with outside diameters 45mm, 60 mm 75 mm or 85 mm

Gas sparger

Porous sparger or L-type sparger

Gas overlay

Yes

Exhaust gas

Water cooled exhaust gas condenser

Sampling

Fixed height or height adjustable sample pipe with optional sampling system

Sample pipe internal diameters choices are: 1.7 mm, 4 mm, 6 mm or 10 mm

Draining

Drain pipe

Additions

Triple or single inlet ports and optional micro liquid injectors

pH

Measurement: 12 mm classic pH sensor

Control: via acid pump or CO2 gas (rotameter or MFC) in combination with alkali pump

DO2

Measurement: 12 mm classic polarographic DO2 sensor

Control: via a combination of N2, Air, O2 (Rotameter or MFC) and agitation or nutrient addition pump

Temperature

Measurement: Pt-100 sensor in thermowell in topplate

Control: cooling and/or heating jacket via bioreactor wall or via internal heat exchanger

Foam

Measurement: Height adjustable conductivity based foam sensor

Control: Anti foam addition pump

Level

Measurement: Height adjustable conductivity based level sensor

Control: pump for liquid addition or removal

Optional inlets

Septum, chemostat tube, liquid entry system

Applications

 

Applications

Microbial and Cell culture configuration
Batch, Fed-Batch, Perfusion and Continuous cultivation

Features of the glass autoclavable bioreactors:

  • Wide range of volumes with interchangeable modules
  • Wide range of modules to tailor the systems to the research demands
  • No welded parts in the bioreactor topplate
  • Simple set-up and easy to handle
  • Optional high torque magnetically coupled agitator
  • All metal parts are constructed of stainless steel 316L to guarantee resistance to pitting and crevice corrosion in chloride environments
  • Mirror polished finish of non product contact stainless steel surface
  • Electropolished finish of product contact stainless steel parts ease cleanability
  • Glass dished bottom vessels are made of borosilicate glass to guarantee:
    • the best resistance to thermal shock
    • excellent corrosion resistance
    • smooth, non porous surface for easy cleaning
    • optimal transparency for visual inspection of the culture
  • Glass bioreactor vessels can be used up to 0.5 barg (7.25 psig) of overpressure.

 

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