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Mini Bioreactors

General

Mini Bioreactors: Real Small, Real bioreactors

MiniBio


Introduction
The MiniBio range of bioreactors (250 ml, 500 ml and 1000 ml total volume) is a true scale down of the laboratory scale bioreactors in the 1 to 15 liter range. The MiniBio systems have the same flexibility as the laboratory scale bioreactors. This means that the MiniBio systems can be customized to fit the demands of any process. The small volume reduces medium costs and reduces the use of expensive bench space.
Functions of mini bioreactors:

  • Generate more data in less time
  • Easy setup and operation
  • Cultivate using less medium
  • Cultivate using les bench space
  • Generate scalable results
  • Mimic lab scale bioreactors
  • Easy data handling

 

MiniBio

Features

Features of the miniBio:

• Generate more data in less time
• Easy setup and operation
• Cultivate using less medium
• Cultivate using less bench space
• Generate scalable results

·     Screening studies

·     Media optimization

·     Process optimization

·     Microbial and Cell culture

Batch, Fed-Batch, Perfusion and Continuous cultivation

Specifications

 

MiniBio 250

MiniBio 500

MiniBio 1000

Total volume (ml)

250

500

1000

Working volume (ml)

200

400

800

Minimum working volume (ml)

50

100

200

Aspect ratio total volume

2.5

2.5

2.5

Aspect ratio working volume

2

2

2

Dimensions (dxh, mm)

 180 x 400  195 x 400  200 x 550

Dimensions for autoclaving (dxh, mm)

 180 x 250 195 x 250   200 x 400

Drive system

Direct drive, lipsealed

Direct drive, lipsealed

Direct drive, lipsealed

Maximum stirrerspeed (rpm)

50 – 2000

50 - 1750

50 - 1500

Maximum impeller tipspeed (m/s)

 2.3 2.0 3.5 

Impellers

Choice of Rushton and marine

Gas sparger

Porous sparger or L-type sparger

Gas overlay

Yes

Exhaust gas

Electrically cooled exhaust gas condenser

(evaporation <5% per day at 37°C @ 2vvm)

Sampling

Fixed sample pipe with optional sampling system

Draining

Height adjustable drain pipe

Additions

4 fixed inlet ports and optional micro liquid injectors

pH

Measurement: 8 mm classic pH sensor

Control: via acid pump (variable speed pump)or CO2 gas in combination with alkali pump (variable speed pump)

DO2

Measurement: 8 mm classic polarographic DO2 sensor

Control: via a combination of N2, Air, O2  (optional MFC) and agitation or nutrient addition (variable speed pump)

Temperature

Measurement: Pt-100 sensor in thermowell in topplate

Control: electrical cooling and heating jacket via bioreactor wall

Foam

Measurement: Height adjustable conductivity based foam sensor

Control: Anti foam addition (variable speed pump)

Level

Measurement: Height adjustable conductivity based level sensor

Control: variable speed pump for liquid addition or removal

Optional inlets

Septum, chemostat tube, liquid entry system

 

MiniBio

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